Phospholipid-transporting ATPase IC

ATP8B1
Identifiers
Aliases	ATP8B1, ATPIC, BRIC, FIC1, ICP1, PFIC, PFIC1, ATPase phospholipid transporting 8B1
External IDs	OMIM: 602397; MGI: 1859665; HomoloGene: 21151; GeneCards: ATP8B1; OMA:ATP8B1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	57,803,315 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	64,794,338 bp
RNA expression pattern
	Top expressed in
	cardia; ; nipple; ; renal medulla; ; pylorus; ; ventral tegmental area; ; trigeminal ganglion; ; buccal mucosa cell; ; superior surface of tongue; ; superior vestibular nucleus; ; subthalamic nucleus;
	Top expressed in
	epithelium of small intestine; ; decidua; ; left colon; ; epithelium of stomach; ; transitional epithelium of urinary bladder; ; jejunum; ; cervix; ; ileum; ; lobe of prostate; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; cardiolipin binding; lipid transporter activity; metal ion binding; protein binding; ATPase-coupled intramembrane lipid transporter activity; hydrolase activity; ATP binding; magnesium ion binding; aminophospholipid flippase activity;
Cellular component	integral component of membrane; Golgi apparatus; cell projection; membrane; plasma membrane; integral component of plasma membrane; stereocilium; brush border membrane; apical plasma membrane; endoplasmic reticulum;
Biological process	regulation of microvillus assembly; lipid transport; Golgi organization; xenobiotic transmembrane transport; bile acid metabolic process; phospholipid transport; hearing; ion transmembrane transport; inner ear receptor cell development; phospholipid translocation; bile acid and bile salt transport; vestibulocochlear nerve formation; negative regulation of transcription, DNA-templated; aminophospholipid transport;
	Sources:Amigo / QuickGO
Orthologs
	5205
	54670
	ENSG00000081923
	ENSMUSG00000039529
	O43520
	Q148W0
	NM_005603; NM_001374385; NM_001374386
	NM_001001488
	NP_005594
	NP_001001488
	Wikidata
View/Edit Human	View/Edit Mouse

Probable phospholipid-transporting ATPase IC is an enzyme that in humans is encoded by the ATP8B1 gene. This protein is associated with progressive familial intrahepatic cholestasis type 1 as well as benign recurrent intrahepatic cholestasis.