ATRX

ATRX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JM1, 2LBM, 2LD1, 3QL9, 3QLA, 3QLC, 3QLN, 4W5A
Identifiers
Aliases	ATRX, ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, MRX52, alpha thalassemia/mental retardation syndrome X-linked, chromatin remodeler, ATRX chromatin remodeler
External IDs	OMIM: 300032; MGI: 103067; HomoloGene: 416; GeneCards: ATRX; OMA:ATRX - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	77,786,233 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	104,973,009 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Achilles tendon; ; epithelium of colon; ; cerebellar vermis; ; Brodmann area 23; ; Epithelium of choroid plexus; ; pylorus; ; tibia; ; sural nerve; ; Region I of hippocampus proper;
	Top expressed in
	genital tubercle; ; tail of embryo; ; pineal gland; ; medullary collecting duct; ; vestibular sensory epithelium; ; condyle; ; fossa; ; lobe of cerebellum; ; Gonadal ridge; ; ciliary body;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; chromo shadow domain binding; helicase activity; histone binding; metal ion binding; DNA translocase activity; methylated histone binding; DNA helicase activity; protein binding; hydrolase activity; ATP binding; chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	PML body; SWI/SNF superfamily-type complex; pericentric heterochromatin; chromosome; heterochromatin; nuclear chromosome; telomere; nucleus; nucleoplasm; nuclear body;
Biological process	chromatin remodeling; nucleosome assembly; DNA recombination; post-embryonic forelimb morphogenesis; regulation of transcription, DNA-templated; multicellular organism growth; DNA damage response, signal transduction by p53 class mediator; positive regulation of nuclear cell cycle DNA replication; Sertoli cell development; transcription, DNA-templated; protein localization to chromosome, telomeric region; cellular response to DNA damage stimulus; positive regulation of telomeric RNA transcription from RNA pol II promoter; positive regulation of telomere maintenance; DNA methylation; negative regulation of telomeric RNA transcription from RNA pol II promoter; seminiferous tubule development; spermatogenesis; replication fork processing; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; forebrain development; DNA repair; cellular response to hydroxyurea; positive regulation of transcription by RNA polymerase II; DNA duplex unwinding; regulation of histone H3-K9 trimethylation; meiotic spindle organization; chromosome organization involved in meiotic cell cycle; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	546
	22589
	ENSG00000085224
	ENSMUSG00000031229
	P46100
	Q61687
	NM_000489; NM_138270; NM_138271
	NM_009530
	NP_000480; NP_612114
	NP_033556
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene.