Ataxin 3

ATXN3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YZB, 2AGA, 2DOS, 2JRI, 2KLZ, 4WTH, 4YS9
Identifiers
Aliases	ATXN3, AT3, ATX3, JOS, MJD, MJD1, SCA3, Ataxin 3
External IDs	OMIM: 607047; MGI: 1099442; HomoloGene: 3658; GeneCards: ATXN3; OMA:ATXN3 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	92,106,621 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	101,958,246 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; epithelium of colon; ; tendon of biceps brachii; ; gonad; ; endothelial cell; ; testicle; ; sural nerve; ; monocyte; ; pericardium; ; right uterine tube;
	Top expressed in
	spermatid; ; morula; ; superior cervical ganglion; ; aortic valve; ; ascending aorta; ; interventricular septum; ; cumulus cell; ; spermatocyte; ; mesenteric lymph nodes; ; epithelium of small intestine;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	Lys63-specific deubiquitinase activity; cysteine-type peptidase activity; ATPase binding; Lys48-specific deubiquitinase activity; peptidase activity; protein binding; identical protein binding; hydrolase activity; thiol-dependent deubiquitinase; ubiquitin protein ligase binding; histone deacetylase activity;
Cellular component	endoplasmic reticulum membrane; nuclear matrix; nucleoplasm; nucleus; nucleolus; cytosol; plasma membrane; cytoplasm; mitochondrial matrix; mitochondrial membranes; nuclear inclusion body;
Biological process	nucleotide-excision repair; regulation of transcription, DNA-templated; protein K48-linked deubiquitination; positive regulation of ERAD pathway; transcription, DNA-templated; nervous system development; proteolysis; protein K63-linked deubiquitination; intermediate filament cytoskeleton organization; protein localization to cytosolic proteasome complex involved in ERAD pathway; microtubule cytoskeleton organization; actin cytoskeleton organization; chemical synaptic transmission; protein deubiquitination; ubiquitin-dependent protein catabolic process; protein quality control for misfolded or incompletely synthesized proteins; regulation of cell-substrate adhesion; cellular response to heat; monoubiquitinated protein deubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; cellular response to misfolded protein; exploration behavior; histone H3 deacetylation;
	Sources:Amigo / QuickGO
Orthologs
	4287
	110616
	ENSG00000066427
	ENSMUSG00000021189
	P54252; Q4VBR4
	Q9CVD2
NM_001024631; NM_001127696; NM_001127697; NM_001164774; NM_001164776;
	NM_001164777; NM_001164778; NM_001164779; NM_001164780; NM_001164781; NM_001164782; NM_004993; NM_030660
	NM_001167914; NM_029705
NP_001121168; NP_001121169; NP_001158246; NP_001158248; NP_001158249;
	NP_001158250; NP_001158251; NP_001158252; NP_001158253; NP_001158254; NP_004984; NP_109376
	NP_001161386; NP_083981
	Wikidata
View/Edit Human	View/Edit Mouse

Ataxin-3 is a protein that in humans is encoded by the ATXN3 gene.