AXIN1

AXIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DK8, 1EMU, 1O9U, 3ZDI, 4B7T, 4NM0, 4NM3, 4NM5, 4NM7, 4NU1
Identifiers
Aliases	AXIN1, AXIN, PPP1R49, axin 1
External IDs	OMIM: 603816; MGI: 1096327; HomoloGene: 2614; GeneCards: AXIN1; OMA:AXIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	352,723 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	26,414,785 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; mucosa of transverse colon; ; right hemisphere of cerebellum; ; gastrocnemius muscle; ; skin of leg; ; mononuclear cell; ; monocyte; ; skin of abdomen; ; blood; ; popliteal artery;
	Top expressed in
	Ileal epithelium; ; tail of embryo; ; ventricular zone; ; genital tubercle; ; epiblast; ; zygote; ; Paneth cell; ; corneal stroma; ; thymus; ; granulocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; protein homodimerization activity; I-SMAD binding; GTPase activator activity; protein binding; enzyme binding; signaling receptor complex adaptor activity; SMAD binding; ubiquitin protein ligase binding; molecular adaptor activity; protein kinase binding; armadillo repeat domain binding; identical protein binding; signaling adaptor activity;
Cellular component	cytoplasm; cytosol; lateral plasma membrane; membrane; plasma membrane; perinuclear region of cytoplasm; cytoplasmic vesicle; nucleus; beta-catenin destruction complex; cell periphery;
Biological process	forebrain anterior/posterior pattern specification; negative regulation of fat cell differentiation; positive regulation of protein phosphorylation; olfactory placode formation; positive regulation of protein catabolic process; positive regulation of canonical Wnt signaling pathway; embryonic eye morphogenesis; negative regulation of Wnt signaling pathway; positive regulation of JNK cascade; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription, DNA-templated; multicellular organism development; lens placode formation; determination of left/right symmetry; canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; positive regulation of ubiquitin-protein transferase activity; positive regulation of peptidyl-threonine phosphorylation; positive regulation of ubiquitin-dependent protein catabolic process; cytoplasmic microtubule organization; canonical Wnt signaling pathway; embryonic skeletal joint morphogenesis; axial mesoderm formation; positive regulation of protein ubiquitination; activation of protein kinase activity; muscle cell development; Wnt-activated signaling pathway involved in forebrain neuron fate commitment; negative regulation of canonical Wnt signaling pathway; signal transduction; apoptotic process; beta-catenin destruction complex disassembly; positive regulation of GTPase activity; Wnt signaling pathway; beta-catenin destruction complex assembly; regulation of Wnt signaling pathway; regulation of intracellular estrogen receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8312
	12005
	ENSG00000103126
	ENSMUSG00000024182
	O15169
	O35625
	NM_003502; NM_181050
	NM_001159598; NM_009733; NM_001394381; NM_001394382; NM_001394389
	NP_003493; NP_851393
	NP_001153070; NP_033863; NP_001381310; NP_001381311; NP_001381318
	Wikidata
View/Edit Human	View/Edit Mouse

Axin-1 is a protein that in humans is encoded by the AXIN1 gene.