AXL receptor tyrosine kinase

AXL
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C5D, 4RA0
Identifiers
Aliases	AXL, AZF, AZFA, SP3, AZF1, ARK, JTK11, Tyro7, UFO, AXL receptor tyrosine kinase
External IDs	OMIM: 109135; MGI: 1347244; HomoloGene: 7583; GeneCards: AXL; OMA:AXL - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,261,766 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	25,488,130 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; saphenous vein; ; stromal cell of endometrium; ; cartilage tissue; ; synovial membrane; ; urethra; ; pericardium; ; decidua; ; popliteal artery; ; tibial arteries;
	Top expressed in
	Gonadal ridge; ; ascending aorta; ; aortic valve; ; umbilical cord; ; ankle joint; ; lip; ; ankle; ; efferent ductule; ; stroma of bone marrow; ; uterus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein kinase activity; transferase activity; virus receptor activity; kinase activity; protein heterodimerization activity; ATP binding; phosphatidylserine binding; protein binding; transmembrane receptor protein tyrosine kinase activity; phosphatidylinositol 3-kinase binding; myosin heavy chain binding; protein tyrosine kinase activity; Wnt-protein binding;
Cellular component	extracellular exosome; integral component of membrane; host cell surface; integral component of plasma membrane; cell surface; membrane; intracellular anatomical structure; plasma membrane; extracellular space; receptor complex;
Biological process	protein kinase B signaling; positive regulation of natural killer cell differentiation; apoptotic cell clearance; negative regulation of lymphocyte activation; spermatogenesis; negative regulation of apoptotic process; signal transduction; natural killer cell differentiation; negative regulation of interferon-gamma production; cellular response to lipopolysaccharide; secretion by cell; vascular endothelial growth factor receptor signaling pathway; substrate adhesion-dependent cell spreading; erythrocyte homeostasis; negative regulation of tumor necrosis factor production; positive regulation of protein kinase B signaling; viral process; positive regulation of cytokine-mediated signaling pathway; cellular response to interferon-alpha; forebrain cell migration; viral entry into host cell; negative regulation of dendritic cell apoptotic process; protein phosphorylation; cellular response to extracellular stimulus; enzyme linked receptor protein signaling pathway; positive regulation of pinocytosis; negative regulation of neuron apoptotic process; vagina development; ovulation cycle; innate immune response; blood vessel remodeling; cell maturation; dendritic cell differentiation; platelet activation; cell differentiation; immune system process; inflammatory response; neuron migration; phosphorylation; cellular response to hydrogen peroxide; animal organ regeneration; phagocytosis; peptidyl-tyrosine phosphorylation; negative regulation of cytokine production; neutrophil clearance; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development; Wnt signaling pathway; cell migration;
	Sources:Amigo / QuickGO
Orthologs
	558
	26362
	ENSG00000167601
	ENSMUSG00000002602
	P30530
	Q00993
	NM_001278599; NM_001699; NM_021913
	NM_001190974; NM_001190975; NM_009465
	NP_001265528; NP_001690; NP_068713
	NP_001177903; NP_001177904; NP_033491
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the unidentified function of this protein. However, in the years since its discovery, research into AXL's expression profile and mechanism has made it an increasingly attractive target, especially for cancer therapeutics. In recent years, AXL has emerged as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers.

AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK.