Adipose triglyceride lipase

PNPLA2
Identifiers
Aliases	PNPLA2, 1110001C14Rik, ATGL, PEDF-R, TTS-2.2, TTS2, iPLA2zeta, FP17548, patatin like phospholipase domain containing 2
External IDs	OMIM: 609059; MGI: 1914103; HomoloGene: 10687; GeneCards: PNPLA2; OMA:PNPLA2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	825,573 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,040,656 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; subcutaneous adipose tissue; ; left coronary artery; ; gastric mucosa; ; right lung; ; mucosa of transverse colon; ; minor salivary glands; ; body of stomach; ; right coronary artery; ; gastrocnemius muscle;
	Top expressed in
	lactiferous gland; ; brown adipose tissue; ; white adipose tissue; ; muscle of thigh; ; subcutaneous adipose tissue; ; tunica adventitia of aorta; ; intercostal muscle; ; interventricular septum; ; cardiac muscles; ; myocardium of ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; lipoprotein lipase activity; acylglycerol O-acyltransferase activity; triglyceride lipase activity;
Cellular component	integral component of membrane; cytosol; lipid droplet; plasma membrane; endoplasmic reticulum membrane; cytoplasm; membrane; nucleoplasm; endoplasmic reticulum lumen;
Biological process	lipid catabolic process; lipid storage; metabolism; negative regulation of sequestering of triglyceride; positive regulation of triglyceride catabolic process; acylglycerol acyl-chain remodeling; lipid droplet organization; lipid metabolism; triglyceride catabolic process; lipid homeostasis; post-translational protein modification; cellular lipid catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	57104
	66853
	ENSG00000177666
	ENSMUSG00000025509
	Q96AD5
	Q8BJ56
	NM_020376
	NM_001163689; NM_025802
	NP_065109
	NP_001157161; NP_080078
	Wikidata
View/Edit Human	View/Edit Mouse

Adipose triglyceride lipase, also known as patatin-like phospholipase domain-containing protein 2 and ATGL, is an enzyme that in humans is encoded by the PNPLA2 gene. ATGL catalyses the first reaction of lipolysis, where triacylglycerols are hydrolysed to diacylglycerols.