Adrenocorticotropic hormone (medication)

Tetracosactide
Clinical data
Trade names	Cortrosyn, Synacthen, Nuvacthen
Other names	Ba 30920; α1–24 corticotrophin; Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro
AHFS/Drugs.com	International Drug Names
ATC code	H01AA02 (WHO) ;
Identifiers
	IUPAC name L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-proline;
CAS Number	16960-16-0 ;
PubChem CID	16129617;
IUPHAR/BPS	6965;
DrugBank	DB01284 ;
ChemSpider	10481947 ;
UNII	72YY86EA29;
KEGG	D00284 ;
ChEBI	CHEBI:3901 ;
ECHA InfoCard	100.037.286
Chemical and physical data
Formula	C136H210N40O31S
Molar mass	2933.49 g·mol−1
	InChI InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86?,88-,89-,90+,91-,92+,93+,94+,95+,96-,97+,98+,99+,100+,101+,102+,103+,104+,105+,109+,110+,111+/m1/s1 ; Key:ZOEFCCMDUURGSE-CQVUSSRSSA-N ;
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Adrenocorticotropic hormone
Clinical data
Trade names	Acortan, Acthar, Acton, Cortigel, Trofocortina
AHFS/Drugs.com	International Drug Names
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH;
PubChem CID	16132265;
DrugBank	DB01285;
ChemSpider	none;
ECHA InfoCard	100.037.286
Chemical and physical data
Formula	C207H308N56O58S
Molar mass	4541.14 g·mol−1

Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test.^{: 316, 1165}^{: 84, 271}

The form that is purified from pig pituitary glands is known as corticotropin^: 316 is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior pituitary gland.^: 84

The form that is made synthetically is tetracosactide, also known as synacthen, tetracosactrin and cosyntropin.^: 1165^: 271 It consists of the first 24 (of a total of 39) amino acids of ACTH and retains full function of the parent peptide.^: 1165 Tetracosactide stimulates the release of corticosteroids such as cortisol from the adrenal glands, and is used for the ACTH stimulation test to assess adrenal gland function.^: 271