Adrenomyeloneuropathy

Adrenomyeloneuropathy (AMN) is a rare hereditary neurodegenerative disorder that primarily affects the spinal cord and peripheral nerves, occurring in less than 1 in 40,000 people. It is characterised by progressive motor dysfunction and adrenal insufficiency. AMN is a form of X-linked adrenoleukodystrophy, a peroxisomal disorder caused by mutations in the ABCD1 gene. Symptoms most commonly begin in a person's late twenties. AMN predominantly affects adult males but heterozygous females may develop symptoms later in life. Treatments mainly center around symptom-management.