Aflatoxin B1

Aflatoxin B₁
	Chemical structure of (−)-aflatoxin B1
	Ball-and-stick model of aflatoxin B1
Names
	Preferred IUPAC name (6aR,9aS)-4-Methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione
	Other names NSC 529592
Identifiers
CAS Number	1162-65-8 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1697694 ;
ChemSpider	13758 ;
ECHA InfoCard	100.013.276
PubChem CID	14403;
UNII	9N2N2Y55MH ;
CompTox Dashboard (EPA)	DTXSID00873175 DTXSID9020035, DTXSID00873175 ;
	InChI InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3 Key: OQIQSTLJSLGHID-UHFFFAOYSA-N ;
	SMILES O=C5C=4C(=O)Oc3c1c(OC2O\C=C/C12)cc(OC)c3C=4CC5;
Properties
Chemical formula	C17H12O6
Molar mass	312.277 g·mol−1
Hazards
	Occupational safety and health (OHS/OSH):
Main hazards	Carcinogen – Mutagen – Acute toxicity / Poison
	GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H300, H310, H330, H340, H350
Precautionary statements	P201, P202, P260, P262, P264, P270, P271, P280, P281, P284, P301+P330+P331, P302+P350, P304+P340, P308+P313, P310, P311, P320, P321, P322, P330, P361, P363, P403+P233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Aflatoxin B₁ is an aflatoxin produced by Aspergillus flavus and A. parasiticus. It is a very potent carcinogen with a TD₅₀ 3.2 μg/kg/day in rats. This carcinogenic potency varies across species with some, such as rats and monkeys, seemingly much more susceptible than others. Aflatoxin B₁ is a common contaminant in a variety of foods including peanuts, cottonseed meal, corn, and other grains; as well as animal feeds. Aflatoxin B₁ is considered the most toxic aflatoxin and it is highly implicated in hepatocellular carcinoma (HCC) in humans. In animals, aflatoxin B₁ has also been shown to be mutagenic, teratogenic, and to cause immunosuppression. Several sampling and analytical methods including thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), mass spectrometry, and enzyme-linked immunosorbent assay (ELISA), among others, have been used to test for aflatoxin B₁ contamination in foods. According to the Food and Agriculture Organization (FAO), a division of the United Nations, the worldwide maximum tolerated levels of aflatoxin B₁ was reported to be in the range of 1–20 μg/kg (or .001 ppm - 1 part-per-billion) in food, and 5–50 μg/kg (.005 ppm) in dietary cattle feed in 2003.

Names
Chemical structure of (−)-aflatoxin B₁
Ball-and-stick model of aflatoxin B₁
Preferred IUPAC name (6aR,9aS)-4-Methoxy-2,3,6a,9a-tetrahydrocyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione
Other names NSC 529592
Identifiers
CAS Number	1162-65-8^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1697694^N
ChemSpider	13758^Y
ECHA InfoCard	100.013.276
PubChem CID	14403
UNII	9N2N2Y55MH^Y
CompTox Dashboard (EPA)	DTXSID00873175 DTXSID9020035, DTXSID00873175
InChI InChI=1S/C17H12O6/c1-20-10-6-11-14(8-4-5-21-17(8)22-11)15-13(10)7-2-3-9(18)12(7)16(19)23-15/h4-6,8,17H,2-3H2,1H3^Y Key: OQIQSTLJSLGHID-UHFFFAOYSA-N^Y
SMILES O=C5C=4C(=O)Oc3c1c(OC2O\C=C/C12)cc(OC)c3C=4CC5
Properties
Chemical formula	C₁₇H₁₂O₆
Molar mass	312.277 g·mol⁻¹
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Carcinogen – Mutagen – Acute toxicity / Poison
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H300, H310, H330, H340, H350
Precautionary statements	P201, P202, P260, P262, P264, P270, P271, P280, P281, P284, P301+P330+P331, P302+P350, P304+P340, P308+P313, P310, P311, P320, P321, P322, P330, P361, P363, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references