Aggrecan

ACAN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MD4
Identifiers
Aliases	ACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, Aggrecan, SSOAOD
External IDs	OMIM: 155760; MGI: 99602; HomoloGene: 136177; GeneCards: ACAN; OMA:ACAN - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	88,875,353 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	78,764,847 bp
RNA expression pattern
	Top expressed in
	tibia; ; cartilage tissue; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; tendon of biceps brachii; ; ascending aorta; ; middle frontal gyrus; ; trachea; ; Achilles tendon;
	Top expressed in
	fossa; ; condyle; ; intercostal muscle; ; tibiofemoral joint; ; trachea; ; ascending aorta; ; ankle; ; skin of external ear; ; lumbar subsegment of spinal cord; ; aortic valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent; metal ion binding; protein binding; hyaluronic acid binding; carbohydrate binding; extracellular matrix structural constituent conferring compression resistance;
Cellular component	extracellular matrix; extracellular region; lysosomal lumen; Golgi lumen; basement membrane; collagen-containing extracellular matrix; perisynaptic extracellular matrix; glutamatergic synapse; GABA-ergic synapse;
Biological process	skeletal system development; extracellular matrix disassembly; extracellular matrix organization; proteolysis; central nervous system development; keratan sulfate catabolic process; keratan sulfate biosynthetic process; cell adhesion; cartilage condensation; chondrocyte development; heart development; proteoglycan biosynthetic process; collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
	176
	11595
	ENSG00000157766
	ENSMUSG00000030607
	P16112
	Q61282
	NM_001135; NM_013227; NM_001369268
	NM_007424; NM_001361500
	NP_001126; NP_037359; NP_001356197
	NP_031450; NP_001348429
	Wikidata
View/Edit Human	View/Edit Mouse

Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.

Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing. Aggrecan was named for its ability to form large aggregates in the cartilage tissue (a large aggregating proteoglycan).