AKT2

AKT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D
Identifiers
Aliases	AKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
External IDs	OMIM: 164731; MGI: 104874; HomoloGene: 48773; GeneCards: AKT2; OMA:AKT2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	40,285,536 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,340,251 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left ovary; ; right ovary; ; body of uterus; ; muscle of thigh; ; canal of the cervix; ; gastrocnemius muscle;
	Top expressed in
	muscle of thigh; ; choroid plexus of fourth ventricle; ; genital tubercle; ; lip; ; granulocyte; ; ascending aorta; ; aortic valve; ; tail of embryo; ; lactiferous gland; ; yolk sac;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; metal ion binding;
Cellular component	cytoplasm; endosome; membrane; plasma membrane; nucleoplasm; ruffle membrane; cell cortex; early endosome; nucleus; cytosol; intracellular membrane-bounded organelle; protein-containing complex; intracellular anatomical structure;
Biological process	positive regulation of protein targeting to membrane; apoptotic process; positive regulation of fatty acid beta-oxidation; insulin receptor signaling pathway; positive regulation of protein phosphorylation; intracellular signal transduction; regulation of cell migration; peripheral nervous system myelin maintenance; positive regulation of glycogen biosynthetic process; positive regulation of cell motility; intracellular protein transmembrane transport; activation of GTPase activity; phosphorylation; positive regulation of glucose metabolic process; mammary gland epithelial cell differentiation; multicellular organism development; protein phosphorylation; negative regulation of long-chain fatty acid import across plasma membrane; glycogen biosynthetic process; positive regulation of vesicle fusion; peptidyl-serine phosphorylation; glucose metabolic process; cellular response to insulin stimulus; glycogen metabolic process; protein localization to plasma membrane; regulation of translation; fat cell differentiation; signal transduction; carbohydrate transport; positive regulation of cell migration; positive regulation of glucose import; cellular response to high light intensity; retinal rod cell apoptotic process; positive regulation of cell population proliferation; positive regulation of mitochondrial membrane potential; negative regulation of apoptotic process; carbohydrate metabolic process; protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	208
	11652
	ENSG00000105221
	ENSMUSG00000004056
	P31751
	Q60823
	NM_001243027; NM_001243028; NM_001626; NM_001330511
	NM_001110208; NM_007434; NM_001331108; NM_001331109
	NP_001229956; NP_001229957; NP_001317440; NP_001617
	NP_001103678; NP_001318037; NP_001318038; NP_031460
	Wikidata
View/Edit Human	View/Edit Mouse

AKT2, also known as RAC-beta serine/threonine-protein kinase, is an enzyme that in humans is encoded by the AKT2 gene. It influences metabolite storage as part of the insulin signal transduction pathway.