Aldolase A

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fructose-bisphosphate aldolase
fructose-bisphosphate aldolase
Identifiers
EC no.	4.1.2.13
CAS no.	9024-52-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

ALDOA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ALD, 2ALD, 4ALD
Identifiers
Aliases	ALDOA, ALDA, GSD12, HEL-S-87p, aldolase, fructose-bisphosphate A, Aldolase A
External IDs	OMIM: 103850; MGI: 87994; HomoloGene: 141054; GeneCards: ALDOA; OMA:ALDOA - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,070,457 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,399,923 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; skeletal muscle tissue; ; superior frontal gyrus; ; apex of heart; ; prefrontal cortex; ; right frontal lobe; ; primary visual cortex; ; left ventricle; ; right auricle of heart;
	Top expressed in
	medial head of gastrocnemius muscle; ; ankle; ; vastus lateralis muscle; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; temporal muscle; ; digastric muscle; ; masseter muscle; ; tibialis anterior muscle; ; knee joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytoskeletal protein binding; tubulin binding; fructose binding; protein binding; catalytic activity; lyase activity; actin binding; fructose-bisphosphate aldolase activity; identical protein binding; RNA binding; cadherin binding;
Cellular component	cytoplasm; M band; membrane; I band; extracellular region; actin cytoskeleton; extracellular exosome; platelet alpha granule lumen; nucleus; extracellular space; cytosol; secretory granule lumen; tertiary granule lumen; ficolin-1-rich granule lumen; sperm head;
Biological process	gluconeogenesis; glycolytic process; muscle cell cellular homeostasis; canonical glycolysis; actin filament organization; fructose metabolic process; platelet degranulation; fructose 1,6-bisphosphate metabolic process; ATP biosynthetic process; regulation of cell shape; protein homotetramerization; striated muscle contraction; neutrophil degranulation; binding of sperm to zona pellucida;
	Sources:Amigo / QuickGO
Orthologs
	226
	11674
	ENSG00000149925
	ENSMUSG00000030695
	P04075
	P05064
NM_000034; NM_001127617; NM_001243175; NM_001243177; NM_184041;
	NM_184043; NM_001355562; NM_001355563; NM_001355564; NM_001355565
	NM_001177307; NM_001177308; NM_007438
	NP_001121089; NP_001230106; NP_908930; NP_908932
	NP_001170778; NP_001170779; NP_031464
	Wikidata
View/Edit Human	View/Edit Mouse

Aldolase A (ALDOA, or ALDA), also known as fructose-bisphosphate aldolase, is an enzyme that in humans is encoded by the ALDOA gene on chromosome 16.

The protein encoded by this gene is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP). Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.