AlkB homolog 5, RNA demethylase

ALKBH5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NJ4, 4NRM, 4NRO, 4NRP, 4NRQ, 4O61, 4O7X, 4OCT
Identifiers
Aliases	ALKBH5, ABH5, OFOXD, OFOXD1, alkB homolog 5, RNA demethylase
External IDs	OMIM: 613303; MGI: 2144489; HomoloGene: 9818; GeneCards: ALKBH5; OMA:ALKBH5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,209,954 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,449,338 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; mucosa of ileum; ; muscle of thigh; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; secondary oocyte;
	Top expressed in
	retinal pigment epithelium; ; ciliary body; ; cumulus cell; ; vestibular membrane of cochlear duct; ; Epithelium of choroid plexus; ; iris; ; submandibular gland; ; vestibular sensory epithelium; ; primary oocyte; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	2-oxoglutarate-dependent dioxygenase activity; oxidoreductase activity; dioxygenase activity; metal ion binding; oxidative RNA demethylase activity; RNA binding; mRNA N6-methyladenosine dioxygenase activity;
Cellular component	nuclear speck; nucleus; nucleoplasm; Golgi apparatus; cytosol;
Biological process	oxidative single-stranded RNA demethylation; mRNA processing; cell differentiation; response to hypoxia; mRNA export from nucleus; spermatogenesis; DNA dealkylation involved in DNA repair; regulation of mRNA stability;
	Sources:Amigo / QuickGO
Orthologs
	54890
	268420
	ENSG00000091542
	ENSMUSG00000042650
	Q6P6C2
	Q3TSG4
	NM_017758
	NM_172943
	NP_060228
	NP_766531
	Wikidata
View/Edit Human	View/Edit Mouse

RNA demethylase ALKBH5 is a protein that in humans is encoded by the ALKBH5 gene.