Alteplase

Alteplase
Clinical data
Trade names	Activase, Actilyse, Cathflo Activase, others
Other names	t-PA, rt-PA
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN US DailyMed: Alteplase
Pregnancy category	AU: B1
Routes of administration	Intravenous
ATC code	B01AD02 (WHO) S01XA13 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only US: ℞-only EU: Rx-only
Identifiers
CAS Number	105857-23-6^Y
DrugBank	DB00009^Y
ChemSpider	none
UNII	1RXS4UE564
KEGG	D02837^Y
Chemical and physical data
Formula	C₂₅₆₉H₃₉₂₈N₇₄₆O₇₈₁S₄₀
Molar mass	59042.52 g·mol⁻¹
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Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. Alteplase is given by injection into a vein or artery. Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis.

It is on the World Health Organization's List of Essential Medicines.