Amelogenesis

Amelogenesis is the process of forming tooth enamel, the hard, protective outer layer of teeth. This process begins during tooth development after the initial formation of dentin (dentinogenesis), the layer beneath the enamel. The inner enamel epithelium (IEE), a layer of cells within the developing tooth, plays a crucial role by signaling the differentiation of specialized cells called ameloblasts, which then secrete the proteins and minerals that make up enamel. The formation of dentin is essential for amelogenesis to occur, and a reciprocal signaling process between the developing dentin and the IEE-derived ameloblasts ensures the proper coordination of these two crucial stages of tooth development.

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