Amifostine

Amifostine
Clinical data
AHFS/Drugs.com	Monograph
Routes of; administration	Intravenous
ATC code	V03AF05 (WHO) ;
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	complete
Elimination half-life	8 minutes
Identifiers
	IUPAC name 2-(3-aminopropylamino)ethylsulfanylphosphonic acid;
CAS Number	112901-68-5 ; anhydrous: 20537-88-6 ;
PubChem CID	2141;
DrugBank	DB01143 ;
ChemSpider	2056 ;
UNII	M487QF2F4V; anhydrous: ILA426L95O ;
KEGG	C06819 ;
ChEBI	CHEBI:2636 ;
ChEMBL	ChEMBL1006 ;
CompTox Dashboard (EPA)	DTXSID8022585 ;
ECHA InfoCard	100.161.827
Chemical and physical data
Formula	C5H15N2O3PS
Molar mass	214.22 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=P(O)(O)SCCNCCCN;
	InChI InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10) ; Key:JKOQGQFVAUAYPM-UHFFFAOYSA-N ;
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Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed by Clinigen Group under the trade name Ethyol.

Clinical data

AHFS/Drugs.com	Monograph
Routes of administration	Intravenous
ATC code	V03AF05 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	complete
Elimination half-life	8 minutes
Identifiers
IUPAC name 2-(3-aminopropylamino)ethylsulfanylphosphonic acid
CAS Number	112901-68-5^Y anhydrous: 20537-88-6^Y
PubChem CID	2141
DrugBank	DB01143^Y
ChemSpider	2056^Y
UNII	M487QF2F4V anhydrous: ILA426L95O^Y
KEGG	C06819^Y
ChEBI	CHEBI:2636^Y
ChEMBL	ChEMBL1006^Y
CompTox Dashboard (EPA)	DTXSID8022585
ECHA InfoCard	100.161.827
Chemical and physical data
Formula	C₅H₁₅N₂O₃PS
Molar mass	214.22 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=P(O)(O)SCCNCCCN
InChI InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)^Y Key:JKOQGQFVAUAYPM-UHFFFAOYSA-N^Y
(verify)