Aminophylline

Aminophylline
Clinical data
AHFS/Drugs.com	Professional Drug Facts
MedlinePlus	a601015
Pregnancy; category	AU: A;
Routes of; administration	By mouth, intravenous therapy (IV)
ATC code	R03DA05 (WHO) ;
Legal status
Legal status	AU: S3 (Pharmacist only); UK: P (Pharmacy medicines); US: ℞-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	60%
Elimination half-life	7–9 hours
Identifiers
	IUPAC name 1,3-Dimethyl-7H-purine-2,6-dione; ethane-1,2-diamine;
CAS Number	317-34-0 ;
PubChem CID	9433;
DrugBank	DB01223 ;
ChemSpider	9062 ;
UNII	27Y3KJK423;
KEGG	D00227 ;
ChEBI	CHEBI:2659;
ChEMBL	ChEMBL1210 ;
CompTox Dashboard (EPA)	DTXSID40883359 ;
ECHA InfoCard	100.005.696
Chemical and physical data
Formula	C16H24N10O4
Molar mass	420.434 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cn2c(=O)c1nc[nH]c1n(C)c2=O.Cn2c(=O)c1nc[nH]c1n(C)c2=O.NCCN;
	InChI InChI=1S/2C7H8N4O2.C2H8N2/c21-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h23H,1-2H3,(H,8,9);1-4H2 ; Key:FQPFAHBPWDRTLU-UHFFFAOYSA-N ;
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Aminophylline is a compound of the bronchodilator theophylline with ethylenediamine in 2:1 ratio. The ethylenediamine improves solubility, and the aminophylline is usually found as a dihydrate.

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of airway obstruction from asthma or COPD. Aminophylline is a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor.