Annexin A5

ANXA5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XO3, 1ANW, 1ANX, 1AVH, 1AVR, 1HAK, 1HVD, 1HVE, 1HVF, 1HVG, 1SAV, 2XO2
Identifiers
Aliases	ANXA5, ANX5, ENX2, HEL-S-7, PP4, RPRGL3, annexin A5, CPB-I, VAC-alph
External IDs	OMIM: 131230; MGI: 106008; HomoloGene: 20312; GeneCards: ANXA5; OMA:ANXA5 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	121,696,995 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	36,530,043 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; smooth muscle tissue; ; Achilles tendon; ; right lung; ; canal of the cervix; ; gallbladder; ; monocyte; ; Descending thoracic aorta; ; ascending aorta; ; islet of Langerhans;
	Top expressed in
	utricle; ; vestibular membrane of cochlear duct; ; stroma of bone marrow; ; right lung lobe; ; vestibular sensory epithelium; ; calvaria; ; molar; ; dermis; ; umbilical cord; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase inhibitor activity; calcium ion binding; protein binding; calcium-dependent phospholipid binding; phospholipid binding; P-type calcium transporter activity; heparin binding; peptide hormone binding; receptor tyrosine kinase binding; molecular adaptor activity;
Cellular component	membrane; focal adhesion; intracellular anatomical structure; endothelial microparticle; extracellular exosome; external side of plasma membrane; extracellular region; cytoplasm; cytosol; collagen-containing extracellular matrix;
Biological process	hemostasis; negative regulation of coagulation; blood coagulation; negative regulation of apoptotic process; response to organic substance; signal transduction; negative regulation of catalytic activity; platelet degranulation; negative regulation of blood coagulation; positive regulation of apoptotic process; protein homooligomerization; negative regulation of sequestering of calcium ion; response to calcium ion; calcium ion transmembrane transport; cellular response to lead ion; response to thyroid hormone; cellular response to gonadotropin-releasing hormone; regulation of flagellated sperm motility; negative regulation of prolactin secretion;
	Sources:Amigo / QuickGO
Orthologs
	308
	11747
	ENSG00000164111
	ENSMUSG00000027712
	P08758
	P48036
	NM_001154
	NM_009673
	NP_001145
	NP_033803
	Wikidata
View/Edit Human	View/Edit Mouse

Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. The function of the protein is unknown; however, annexin A5 has been proposed to play a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These properties have been found by in vitro experiments.