Apelin receptor

APLNR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LOT, 2LOU, 2LOV, 2LOW
Identifiers
Aliases	APLNR, AGTRL1, APJ, APJR, HG11, apelin receptor
External IDs	OMIM: 600052; MGI: 1346086; HomoloGene: 3784; GeneCards: APLNR; OMA:APLNR - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	57,237,250 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,970,267 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; inferior olivary nucleus; ; dorsal motor nucleus of vagus nerve; ; tendon of biceps brachii; ; ventral tegmental area; ; spinal cord; ; C1 segment; ; Region I of hippocampus proper; ; myocardium of left ventricle; ; spleen;
	Top expressed in
	renal corpuscle; ; left lung lobe; ; dermis; ; medullary collecting duct; ; body of femur; ; vas deferens; ; internal carotid artery; ; primitive streak; ; digastric muscle; ; migratory enteric neural crest cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; signaling receptor activity; apelin receptor activity;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane;
Biological process	multicellular organism development; heart development; regulation of body fluid levels; gastrulation; signal transduction; G protein-coupled receptor signaling pathway; negative regulation of cAMP-mediated signaling; positive regulation of angiogenesis; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of inhibitory G protein-coupled receptor phosphorylation; vasculogenesis; adult heart development; coronary vasculature development; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; angiogenesis; blood vessel development; apelin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	187
	23796
	ENSG00000134817
	ENSMUSG00000044338
	P35414
	Q9WV08
	NM_005161
	NM_011784
	NP_005152
	NP_035914
	Wikidata
View/Edit Human	View/Edit Mouse

The Apelin Receptor (APLNR, also known as APJ) is a G protein-coupled receptor. APLNR possesses two endogenous ligands which are APELIN and ELABELA. The structure of APLNR was resolved in 2017