Aquaporin-2

AQP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OJ2, 4NEF
Identifiers
Aliases	AQP2, AQP-CD, WCH-CD, aquaporin 2, NDI2
External IDs	OMIM: 107777; MGI: 1096865; HomoloGene: 20137; GeneCards: AQP2; OMA:AQP2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,958,878 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	99,482,428 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; seminal vesicula; ; sperm; ; kidney tubule; ; human kidney; ; testicle; ; tail of epididymis; ; buccal mucosa cell; ; glomerulus; ; metanephric glomerulus;
	Top expressed in
	right kidney; ; human kidney; ; gastrula; ; renal cortex; ; lobe of prostate; ; proximal tubule; ; metanephros; ; skin of external ear; ; medullary collecting duct; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transporter activity; glycerol transmembrane transporter activity; water transmembrane transporter activity; water channel activity; protein binding; channel activity;
Cellular component	integral component of membrane; recycling endosome; Golgi apparatus; membrane; plasma membrane; transport vesicle membrane; basolateral plasma membrane; apical plasma membrane; extracellular exosome; cytoplasmic vesicle membrane; cytoplasmic vesicle; integral component of plasma membrane; lumenal side of membrane;
Biological process	cellular response to mercury ion; excretion; water transport; ion transmembrane transport; renal water transport; renal water homeostasis; cellular response to copper ion; metanephric collecting duct development; cellular response to water deprivation; glycerol transport; transport; transmembrane transport; protein homotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	359
	11827
	ENSG00000167580
	ENSMUSG00000023013
	P41181
	P56402
	NM_000486
	NM_009699
	NP_000477
	NP_033829
	Wikidata
View/Edit Human	View/Edit Mouse

Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. It is encoded by the AQP2 gene.