Aralkylamine N-acetyltransferase
| Aralkylamine N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
Crystallographic structure of aralkylamine N-acetyltransferase. | |||||||||
| Identifiers | |||||||||
| EC no. | 2.3.1.87 | ||||||||
| CAS no. | 92941-56-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| Aralkylamine N-acetyltransferase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | AANAT | ||||||
| NCBI gene | 15 | ||||||
| HGNC | 19 | ||||||
| OMIM | 600950 | ||||||
| RefSeq | NM_001088 | ||||||
| UniProt | Q16613 | ||||||
| Other data | |||||||
| EC number | 2.3.1.87 | ||||||
| Locus | Chr. 17 q25 | ||||||
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Aralkylamine N-acetyltransferase (AANAT) (EC 2.3.1.87), also known as arylalkylamine N-acetyltransferase or serotonin N-acetyltransferase (SNAT), is an enzyme that is involved in the day/night rhythmic production of melatonin, by modification of serotonin. It is in humans encoded by the ~2.5 kb AANAT gene containing four exons, located on chromosome 17q25. The gene is translated into a 23 kDa large enzyme. It is well conserved through evolution and the human form of the protein is 80 percent identical to sheep and rat AANAT. It is an acetyl-CoA-dependent enzyme of the GCN5-related family of N-acetyltransferases (GNATs). It may contribute to multifactorial genetic diseases such as altered behavior in sleep/wake cycle and research is on-going with the aim of developing drugs that regulate AANAT function.