Aristides Leão

Aristides Leão
Born(1914-08-03)August 3, 1914
DiedDecember 14, 1993(1993-12-14) (aged 79)
São Paulo, Brazil
Resting placeRio de Janeiro
Alma materFMUSP (graduation)
Harvard University (M.A., 1942 - PhD, 1943)
Known forDiscovery of cortical spreading depression
SpouseElisabeth Raja Gabaglia Leão aka Elisabeth Pacheco Leão
RelativesCandido Portinari (brother-in-law)
AwardsGrand Cross of the National Order of Scientific Merit (1994)
Scientific career
FieldsNeurophysiology
InstitutionsFederal University of Rio de Janeiro
Instituto de Biofísica Carlos Chagas Filho
ThesisSpreading depression of activity in the cerebral cortex (1944)
Doctoral advisorArturo Rosenblueth
Hallowell Davis

Aristides Azevedo Pacheco Leão (August 3, 1914, in Rio de Janeiro – December 14, 1993, in São Paulo) was a Brazilian neurophysiologist, researcher and university professor.

Leão discovered and described the spreading depression, which also became known as "the Leão wave". This depression is a reaction in the cerebral cortex that can be induced by touch or electric shock, although, more significantly, it occurs spontaneously in migraine and to some extent in epilepsy. It occurs not only in the brain, but in other neural structures.

Leão was president of the Brazilian Academy of Sciences between 1967 and 1981 and defended scientists persecuted by the military dictatorship. He created scientific journals and built important scientific collaborations between the academy and other scientific bodies. Elected president emeritus of the institution, he was awarded the Grand Cross of the National Order of Scientific Merit. The academy's library now bears his name.