Arrestin
| S-antigen; retina and pineal gland (arrestin) | |||||||
|---|---|---|---|---|---|---|---|
Crystallographic structure of the bovine arrestin-S. | |||||||
| Identifiers | |||||||
| Symbol | SAG | ||||||
| Alt. symbols | arrestin-1 | ||||||
| NCBI gene | 6295 | ||||||
| HGNC | 10521 | ||||||
| OMIM | 181031 | ||||||
| RefSeq | NM_000541 | ||||||
| UniProt | P10523 | ||||||
| Other data | |||||||
| Locus | Chr. 2 q37.1 | ||||||
| |||||||
| arrestin beta 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARRB1 | ||||||
| Alt. symbols | ARR1, arrestin-2 | ||||||
| NCBI gene | 408 | ||||||
| HGNC | 711 | ||||||
| OMIM | 107940 | ||||||
| RefSeq | NM_004041 | ||||||
| UniProt | P49407 | ||||||
| Other data | |||||||
| Locus | Chr. 11 q13 | ||||||
| |||||||
| arrestin beta 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARRB2 | ||||||
| Alt. symbols | ARR2, arrestin-3 | ||||||
| NCBI gene | 409 | ||||||
| HGNC | 712 | ||||||
| OMIM | 107941 | ||||||
| RefSeq | NM_004313 | ||||||
| UniProt | P32121 | ||||||
| Other data | |||||||
| Locus | Chr. 17 p13 | ||||||
| |||||||
| arrestin 3, retinal (X-arrestin) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ARR3 | ||||||
| Alt. symbols | ARRX, arrestin-4 | ||||||
| NCBI gene | 407 | ||||||
| HGNC | 710 | ||||||
| OMIM | 301770 | ||||||
| RefSeq | NM_004312 | ||||||
| UniProt | P36575 | ||||||
| Other data | |||||||
| Locus | Chr. X q | ||||||
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Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors. Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall, and Ursula Wilden and in the β-adrenergic system by Martin J. Lohse and co-workers.