Aspartame

Aspartame
Names
Pronunciation	/ˈæspərteɪm/ or ; /əˈspɑːrteɪm/
	IUPAC name Methyl L-α-aspartyl-L-phenylalaninate
	Systematic IUPAC name (3S)-3-amino-4-「[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino」-4-oxobutanoic acid
	Other names N-(L-α-Aspartyl)-L-phenylalanine; 1-methyl ester;
Identifiers
CAS Number	22839-47-0 ;
3D model (JSmol)	Interactive image;
Beilstein Reference	2223850
ChEBI	CHEBI:2877 ;
ChEMBL	ChEMBL171679 ;
ChemSpider	118630 ;
DrugBank	DB00168 ;
ECHA InfoCard	100.041.132
EC Number	245-261-3;
E number	E951 (glazing agents, ...)
KEGG	C11045 ;
PubChem CID	134601;
UNII	Z0H242BBR1 ;
CompTox Dashboard (EPA)	DTXSID0020107 ;
	InChI InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1 Key: IAOZJIPTCAWIRG-QWRGUYRKSA-N ; InChI=1/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1 Key: IAOZJIPTCAWIRG-QWRGUYRKBV;
	SMILES O=C(O)C[C@H](N)C(=O)N[C@H](C(=O)OC)Cc1ccccc1;
Properties
Chemical formula	C14H18N2O5
Molar mass	294.307 g·mol−1
Density	1.347 g/cm3
Melting point	246.5 °C (475.7 °F; 519.6 K)
Boiling point	Decomposes
Solubility in water	Sparingly soluble
Solubility	Slightly soluble in ethanol
Acidity (pKa)	4.5–6.0
Hazards
NFPA 704 (fire diamond)	1 1 0
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Aspartame is an artificial non-saccharide sweetener commonly used as a sugar substitute in foods and beverages. 200 times sweeter than sucrose, it is a methyl ester of the aspartic acid/phenylalanine dipeptide with brand names NutraSweet, Equal, and Canderel. Discovered in 1965, aspartame was approved by the US Food and Drug Administration (FDA) in 1974 and re-approved in 1981 after its initial approval was briefly revoked.

Aspartame is one of the most studied food additives in the human food supply. Reviews by over 100 governmental regulatory bodies found the ingredient safe for consumption at the normal acceptable daily intake limit.

Names



Pronunciation	/ˈæspərteɪm/ or /əˈspɑːrteɪm/
IUPAC name Methyl L-α-aspartyl-L-phenylalaninate
Systematic IUPAC name (3S)-3-amino-4-「[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino」-4-oxobutanoic acid
Other names N-(L-α-Aspartyl)-L-phenylalanine 1-methyl ester
Identifiers
CAS Number	22839-47-0^Y
3D model (JSmol)	Interactive image
Beilstein Reference	2223850
ChEBI	CHEBI:2877^Y
ChEMBL	ChEMBL171679^Y
ChemSpider	118630^Y
DrugBank	DB00168^Y
ECHA InfoCard	100.041.132
EC Number	245-261-3
E number	E951 (glazing agents, ...)
KEGG	C11045^Y
PubChem CID	134601
UNII	Z0H242BBR1^Y
CompTox Dashboard (EPA)	DTXSID0020107
InChI InChI=1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1^Y Key: IAOZJIPTCAWIRG-QWRGUYRKSA-N^Y InChI=1/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1 Key: IAOZJIPTCAWIRG-QWRGUYRKBV
SMILES O=C(O)C[C@H](N)C(=O)N[C@H](C(=O)OC)Cc1ccccc1
Properties
Chemical formula	C₁₄H₁₈N₂O₅
Molar mass	294.307 g·mol⁻¹
Density	1.347 g/cm³
Melting point	246.5 °C (475.7 °F; 519.6 K)
Boiling point	Decomposes
Solubility in water	Sparingly soluble
Solubility	Slightly soluble in ethanol
Acidity (pK_a)	4.5–6.0
Hazards
NFPA 704 (fire diamond)	1 1 0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is ^YN ?) Infobox references