Avatrombopag

Avatrombopag
Clinical data
Pronunciation	a" va trom' boe pag
Trade names	Doptelet
AHFS/Drugs.com	Monograph
MedlinePlus	a618032
License data	US DailyMed: Avatrombopag;
Pregnancy; category	AU: B3;
Routes of; administration	By mouth
ATC code	B02BX08 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); CA: ℞-only; US: ℞-only; EU: Rx-only; In general: ℞ (Prescription only);
Identifiers
	IUPAC name 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid;
CAS Number	570406-98-3 ;
PubChem CID	9852519;
DrugBank	DB11995 ;
ChemSpider	8028230 ;
UNII	3H8GSZ4SQL;
KEGG	D10306; as salt: D10307;
ChEMBL	ChEMBL2103883 ;
CompTox Dashboard (EPA)	DTXSID30205667 ;
Chemical and physical data
Formula	C29H34Cl2N6O3S2
Molar mass	649.65 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl;
	InChI InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38) ; Key:OFZJKCQENFPZBH-UHFFFAOYSA-N;
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Avatrombopag, sold under the brand name Doptelet, is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure. It was approved for medical use in the United States in May 2018, the European Union in June 2019, and Australia in January 2023.

It acts as a thrombopoietin receptor agonist.