B3GALT5

B3GALT5
Identifiers
Aliases	B3GALT5, B3GalT-V, B3GalTx, B3T5, GLCT5, beta-1,3-GalTase 5, beta-3-Gx-T5, beta3Gal-T5, beta-1,3-galactosyltransferase 5
External IDs	OMIM: 604066; MGI: 2136878; HomoloGene: 13230; GeneCards: B3GALT5; OMA:B3GALT5 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	39,673,137 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	96,121,059 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; mucosa of sigmoid colon; ; jejunal mucosa; ; rectum; ; duodenum; ; mucosa of transverse colon; ; amniotic fluid; ; sperm; ; gonad; ; mucosa of ileum;
	Top expressed in
	left colon; ; interventricular septum; ; lumbar subsegment of spinal cord; ; anterior horn of spinal cord; ; facial motor nucleus; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; deep cerebellar nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; galactosyltransferase activity; glycosyltransferase activity; acetylgalactosaminyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum; membrane;
Biological process	protein glycosylation; protein N-linked glycosylation; oligosaccharide biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	10317
	93961
	ENSG00000183778
	ENSMUSG00000074892
	Q9Y2C3
	Q9JI67
NM_033173; NM_001278650; NM_006057; NM_033170; NM_033171;
	NM_033172; NM_001356336; NM_001356338; NM_001356339
	NM_001122993; NM_033149; NM_001358389; NM_001358390
NP_001265579; NP_006048; NP_149360; NP_149361; NP_149362;
	NP_001343265; NP_001343267; NP_001343268
	NP_001116465; NP_149161; NP_001345318; NP_001345319
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-1,3-galactosyltransferase 5 is an enzyme that in humans is encoded by the B3GALT5 gene.

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes the most probable candidate for synthesis of the type 1 Lewis antigens which are frequently found to be elevated in gastrointestinal and pancreatic cancers. The encoded protein is inactive with N-linked glycoproteins and functions in mucin glycosylation. Five transcript variants have been described which differ in the 5' UTR. All transcript variants encode an identical protein.