B3GAT1

B3GAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V82, 1V83, 1V84
Identifiers
Aliases	B3GAT1, CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, beta-1,3-glucuronyltransferase 1
External IDs	OMIM: 151290; MGI: 1924148; HomoloGene: 49551; GeneCards: B3GAT1; OMA:B3GAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	134,412,242 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	26,674,397 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right frontal lobe; ; Amygdala; ; anterior cingulate cortex; ; prefrontal cortex; ; Brodmann area 9; ; hippocampus proper; ; putamen; ; nucleus accumbens; ; Region I of hippocampus proper;
	Top expressed in
	habenula; ; visual cortex; ; primary visual cortex; ; piriform cortex; ; superior frontal gyrus; ; subiculum; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; lateral septal nucleus; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; metal ion binding; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; extracellular region; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; Golgi membrane;
Biological process	glycosaminoglycan metabolic process; protein glycosylation; chondroitin sulfate proteoglycan biosynthetic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; cellular response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	27087
	76898
	ENSG00000109956
	ENSMUSG00000045994
	Q9P2W7
	Q9CW73
	NM_018644; NM_054025; NM_001367973
	NM_029792; NM_001310766
	NP_061114; NP_473366; NP_001354902
	NP_001297695; NP_084068
	Wikidata
View/Edit Human	View/Edit Mouse

3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins. In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system.