Beta-1,3-N-acetylglucosaminyltransferase 3

B3GNT3
Identifiers
Aliases	B3GNT3, B3GAL-T8, B3GN-T3, B3GNT-3, HP10328, TMEM3, beta3Gn-T3, Beta-1,3-N-acetylglucosaminyltransferase 3, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
External IDs	OMIM: 605863; MGI: 2152535; HomoloGene: 113516; GeneCards: B3GNT3; OMA:B3GNT3 - orthologs
EC number	2.4.1.146
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,813,576 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	72,154,433 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; gallbladder; ; mucosa of sigmoid colon; ; duodenum; ; nasal epithelium; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; body of stomach; ; jejunal mucosa;
	Top expressed in
	epithelium of stomach; ; duodenum; ; pyloric antrum; ; jejunum; ; intestinal villus; ; large intestine; ; mucous cell of stomach; ; colon; ; left colon; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity; transferase activity; galactosyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity; acetylgalactosaminyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; integral component of plasma membrane; membrane; endoplasmic reticulum;
Biological process	protein glycosylation; poly-N-acetyllactosamine biosynthetic process; keratan sulfate biosynthetic process; O-glycan processing;
	Sources:Amigo / QuickGO
Orthologs
	10331
	72297
	ENSG00000179913
	ENSMUSG00000031803
	Q9Y2A9
	Q5JCS9
	NM_014256
	NM_028189
	NP_055071
	NP_082465
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 is an enzyme that in humans is encoded by the B3GNT3 gene.

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein and contains a signal anchor that is not cleaved. It prefers the substrates of lacto-N-tetraose and lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains and the biosynthesis of the backbone structure of dimeric sialyl Lewis a. It plays dominant roles in L-selectin ligand biosynthesis, lymphocyte homing and lymphocyte trafficking.