B4GALNT1

B4GALNT1
Identifiers
Aliases	B4GALNT1, GALGT, GALNACT, GalNAc-T, SPG26, beta-1,4-N-acetyl-galactosaminyltransferase 1
External IDs	OMIM: 601873; MGI: 1342057; HomoloGene: 1133; GeneCards: B4GALNT1; OMA:B4GALNT1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,633,239 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,008,199 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex; ; Brodmann area 9; ; ganglionic eminence; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens; ; caudate nucleus; ; putamen;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; duodenum; ; epithelium of stomach; ; pyloric antrum; ; jejunum; ; superior frontal gyrus; ; mesenteric lymph nodes; ; primary visual cortex; ; granulocyte; ; parotid gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hexosyltransferase activity; glycosyltransferase activity; acetylgalactosaminyltransferase activity; transferase activity; (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity;
Cellular component	Golgi apparatus; plasma membrane; membrane; integral component of Golgi membrane; integral component of membrane; Golgi membrane;
Biological process	glycosphingolipid metabolic process; spermatogenesis; lipid glycosylation; lipid storage; ganglioside biosynthetic process; lipid metabolism; sphingolipid metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2583
	14421
	ENSG00000135454
	ENSMUSG00000006731
	Q00973
	Q09200
	NM_001276468; NM_001276469; NM_001478
NM_001244617; NM_001244618; NM_008080; NM_027739; NM_001358577;
	NM_001358578
	NP_001263397; NP_001263398; NP_001469
NP_001231546; NP_001231547; NP_032106; NP_082015; NP_001345506;
	NP_001345507
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene.

GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively.