BAALC

brain and acute leukemia, cytoplasmic
Identifiers
SymbolBAALC
NCBI gene79870
HGNC14333
OMIM606602
RefSeqNP_079088.1 NP_001019543.1 NP_079088.1
UniProtQ8WXS3
Other data
LocusChr. 8 q22.3
Search for
StructuresSwiss-model
DomainsInterPro

BAALC is a gene that codes for the brain and acute leukemia cytoplasmic protein. The official symbol (BAALC) and official name (brain and acute leukemia cytoplasmic) is maintained by the HGNC. The function of BAALC is not fully understood yet, but has been suggested to have synaptic roles involving the post synaptic lipid raft. Lipid rafts are microdomains that are enriched with cholesterol and sphingolipids, lipid raft functions include membrane trafficking, signal processing, and regulation of the actin cytoskeleton. The postsynaptic lipid raft possesses many proteins and is one of the major sites for signal processing and postsynaptic density (PSD). Along with its involvement in the post synaptic lipid rafts, BAALC expression has been associated with Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia.