Beta-secretase 2

BACE2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EWY, 3ZKG, 3ZKI, 3ZKM, 3ZKN, 3ZKQ, 3ZKS, 3ZKX, 3ZL7, 3ZLQ, 4BEL, 4BFB
Identifiers
Aliases	BACE2, AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP, beta-site APP-cleaving enzyme 2, beta-secretase 2
External IDs	OMIM: 605668; MGI: 1860440; HomoloGene: 22696; GeneCards: BACE2; OMA:BACE2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	41,282,530 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	97,244,136 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; gallbladder; ; pancreatic ductal cell; ; minor salivary glands; ; renal medulla; ; islet of Langerhans; ; pylorus; ; ascending aorta; ; Descending thoracic aorta; ; saphenous vein;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; transitional epithelium of urinary bladder; ; islet of Langerhans; ; iris; ; mucous cell of stomach; ; sciatic nerve; ; conjunctival fornix; ; aortic valve; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; amyloid-beta binding; hydrolase activity; aspartic-type endopeptidase activity;
Cellular component	integral component of membrane; cell surface; endosome; Golgi apparatus; endoplasmic reticulum; membrane; plasma membrane; cytoplasm; trans-Golgi network; dense core granule;
Biological process	peptide hormone processing; protein catabolic process; amyloid-beta metabolic process; negative regulation of amyloid precursor protein biosynthetic process; proteolysis; membrane protein ectodomain proteolysis; astrocyte activation; glucose homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	25825
	56175
	ENSG00000182240
	ENSMUSG00000040605
	Q9Y5Z0
	Q9JL18
	NM_138992; NM_012105; NM_138991
	NM_019517
	NP_036237; NP_620476; NP_620477
	NP_062390
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-secretase 2 (EC 3.4.23.45, also known as Memapsin-1) is an enzyme that cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. BACE2 is a close homolog of BACE1.