BAG5

BAG5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D9D, 3A8Y
Identifiers
Aliases	BAG5, BAG-5, BCL2 associated athanogene 5, BAG cochaperone 5, CMD2F
External IDs	OMIM: 603885; MGI: 1917619; HomoloGene: 3584; GeneCards: BAG5; OMA:BAG5 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,562,657 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,679,691 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; skin of thigh; ; skin of hip; ; endothelial cell; ; caput epididymis; ; gums; ; corpus epididymis; ; gingival epithelium;
	Top expressed in
	seminiferous tubule; ; spermatid; ; saccule; ; otic vesicle; ; spermatocyte; ; otic placode; ; supraoptic nucleus; ; dorsal striatum; ; interventricular septum; ; aortic valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chaperone binding; protein binding; protein kinase binding; ubiquitin protein ligase binding; adenyl-nucleotide exchange factor activity;
Cellular component	cytosol; membrane; mitochondrion; inclusion body; perinuclear region of cytoplasm; nucleus;
Biological process	neuron death; negative regulation of neuron projection development; Golgi organization; regulation of inclusion body assembly; negative regulation of protein ubiquitination; protein folding; negative regulation of ubiquitin-protein transferase activity; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of cellular response to heat; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of protein refolding; regulation of ubiquitin-protein transferase activity; protein stabilization;
	Sources:Amigo / QuickGO
Orthologs
	9529
	70369
	ENSG00000166170
	ENSMUSG00000049792
	Q9UL15
	Q8CI32
	NM_004873; NM_001015048; NM_001015049
	NM_027404; NM_001324480; NM_001324481; NM_001324482
	NP_001015048; NP_001015049; NP_004864
	NP_001311409; NP_001311410; NP_001311411; NP_081680
	Wikidata
View/Edit Human	View/Edit Mouse

BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.