BAIAP3

BAIAP3
Identifiers
Aliases	BAIAP3, BAP3, BAI1 associated protein 3
External IDs	OMIM: 604009; MGI: 2685783; HomoloGene: 20844; GeneCards: BAIAP3; OMA:BAIAP3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,349,441 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,475,338 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; Hypothalamus; ; Amygdala; ; olfactory zone of nasal mucosa; ; prefrontal cortex;
	Top expressed in
	arcuate nucleus; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; median eminence; ; paraventricular nucleus of hypothalamus; ; suprachiasmatic nucleus; ; lateral hypothalamus; ; nucleus of stria terminalis; ; central gray substance of midbrain; ; ventral tegmental area;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	syntaxin binding; SNARE binding; calcium ion binding; protein binding; phospholipid binding;
Cellular component	presynapse; endoplasmic reticulum; dense core granule; early endosome membrane; cytosol; plasma membrane; late endosome membrane; trans-Golgi network membrane; recycling endosome membrane; cytoplasm; endosome; Golgi apparatus; membrane;
Biological process	G protein-coupled receptor signaling pathway; dense core granule maturation; positive regulation of neurotransmitter secretion; regulation of synaptic transmission, GABAergic; positive regulation of insulin secretion involved in cellular response to glucose stimulus; retrograde transport, endosome to Golgi; regulation of dense core granule exocytosis; exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	8938
	545192
	ENSG00000007516
	ENSMUSG00000047507
	O94812
	Q80TT2
NM_001199096; NM_001199097; NM_001199098; NM_001199099; NM_001286464;
	NM_003933
	NM_001163270
NP_001186025; NP_001186026; NP_001186027; NP_001186028; NP_001273393;
	NP_003924
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

BAI1-associated protein 3 is a protein that in humans is encoded by the BAIAP3 gene.

BAIAP3 was identified as a protein-binding partner of BAI1. BAI1 is a p53-target gene that encodes a brain-specific angiogenesis inhibitor. The protein is a seven-span transmembrane protein and a member of the secretin receptor family. BAIAP3 interacts with the cytoplasmic region of brain-specific angiogenesis inhibitor 1. BAIAP3 also contains two C2 domains, which are often found in proteins involved in signal transduction or membrane trafficking. Its expression pattern and similarity to other proteins suggest that it may be involved in synaptic functions.