Bcl-2 homologous antagonist killer

BAK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI
Identifiers
Aliases	BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1
External IDs	OMIM: 600516; MGI: 1097161; HomoloGene: 917; GeneCards: BAK1; OMA:BAK1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,580,293 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; granulocyte; ; left adrenal gland; ; left adrenal cortex; ; right adrenal gland; ; monocyte; ; apex of heart; ; duodenum; ; right adrenal cortex; ; rectum;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane transporter binding; metal ion binding; protein binding; identical protein binding; protein homodimerization activity; molecular function; heat shock protein binding; protein heterodimerization activity; chaperone binding; BH domain binding;
Cellular component	integral component of membrane; cytosol; membrane; mitochondrial membranes; integral component of mitochondrial outer membrane; intracellular anatomical structure; endoplasmic reticulum; mitochondrion; pore complex; mitochondrial outer membrane; BAK complex;
Biological process	mitochondrial fusion; leukocyte homeostasis; regulation of apoptotic process; positive regulation of endoplasmic reticulum unfolded protein response; establishment or maintenance of transmembrane electrochemical gradient; limb morphogenesis; positive regulation of calcium ion transport into cytosol; response to organic cyclic compound; B cell apoptotic process; regulation of protein heterodimerization activity; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; vagina development; homeostasis of number of cells; cellular response to UV; myeloid cell homeostasis; ageing; post-embryonic camera-type eye morphogenesis; B cell homeostasis; thymocyte apoptotic process; endoplasmic reticulum calcium ion homeostasis; negative regulation of gene expression; regulation of cell cycle; regulation of mitochondrial membrane potential; positive regulation of IRE1-mediated unfolded protein response; blood vessel remodeling; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; brain development; response to fungus; regulation of mitochondrial membrane permeability; cellular response to mechanical stimulus; fibroblast apoptotic process; activation of cysteine-type endopeptidase activity; apoptotic process involved in blood vessel morphogenesis; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; animal organ regeneration; negative regulation of peptidyl-serine phosphorylation; positive regulation of proteolysis; positive regulation of release of cytochrome c from mitochondria; apoptotic signaling pathway; negative regulation of endoplasmic reticulum calcium ion concentration; cell population proliferation; response to ethanol; activation of cysteine-type endopeptidase activity involved in apoptotic process; response to gamma radiation; regulation of protein homodimerization activity; response to UV-C; response to hydrogen peroxide; endocrine pancreas development; release of cytochrome c from mitochondria; B cell negative selection; negative regulation of cell population proliferation; response to mycotoxin; positive regulation of apoptotic process; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand; apoptotic process; Unfolded Protein Response;
	Sources:Amigo / QuickGO
Orthologs
	578
	12018
	ENSG00000030110
	ENSMUSG00000057789
	Q16611
	O08734
	NM_001188
	NM_007523
	NP_001179
	NP_031549
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2 homologous antagonist/killer is a protein which in humans is encoded by the BAK1 gene on chromosome 6. It belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.