BAP1

BAP1
Identifiers
Aliases	BAP1, HUCEP-13, UCHL2, hucep-6, BRCA1 associated protein 1, KURIS
External IDs	OMIM: 603089; MGI: 1206586; HomoloGene: 3421; GeneCards: BAP1; OMA:BAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	52,410,008 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	30,981,901 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right frontal lobe; ; anterior cingulate cortex; ; prefrontal cortex; ; Amygdala; ; right hemisphere of cerebellum; ; skin of abdomen; ; skin of leg; ; Brodmann area 9;
	Top expressed in
	Rostral migratory stream; ; condyle; ; fossa; ; motor neuron; ; vas deferens; ; facial motor nucleus; ; Paneth cell; ; abdominal wall; ; temporal lobe; ; piriform cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; hydrolase activity; chromatin binding; cysteine-type peptidase activity; thiol-dependent deubiquitinase; protein binding;
Cellular component	cytoplasm; PR-DUB complex; intracellular anatomical structure; nucleus; nucleoplasm; cytosol;
Biological process	ubiquitin-dependent protein catabolic process; regulation of cell cycle; negative regulation of cell population proliferation; proteolysis; regulation of cell growth; monoubiquitinated protein deubiquitination; positive regulation of protein targeting to mitochondrion; protein K48-linked deubiquitination; monoubiquitinated histone H2A deubiquitination; response to inorganic substance; protein deubiquitination; regulation of inflammatory response; macrophage homeostasis; regulation of cytokine production involved in inflammatory response; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	8314
	104416
	ENSG00000163930
	ENSMUSG00000021901
	Q92560
	Q99PU7
	NM_004656
	NM_027088
	NP_004647
	NP_081364
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. BAP1 encodes an 80.4 kDa nuclear-localizing protein with a ubiquitin carboxy-terminal hydrolase (UCH) domain that gives BAP1 its deubiquitinase activity. Recent studies have shown that BAP1 and its fruit fly homolog, Calypso, are members of the polycomb-group proteins (PcG) of highly conserved transcriptional repressors required for long-term silencing of genes that regulate cell fate determination, stem cell pluripotency, and other developmental processes.