BARD1

BARD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JM7, 2NTE, 2R1Z, 3C5R, 3FA2
Identifiers
Aliases	BARD1, BRCA1 associated RING domain 1
External IDs	OMIM: 601593; MGI: 1328361; HomoloGene: 400; GeneCards: BARD1; OMA:BARD1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	214,809,683 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	71,142,305 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; nipple; ; testicle; ; gonad; ; Achilles tendon; ; saphenous vein; ; buccal mucosa cell; ; human penis; ; mucosa of pharynx; ; bone marrow;
	Top expressed in
	secondary oocyte; ; zygote; ; urethra; ; spermatocyte; ; male urethra; ; tail of embryo; ; ventricular zone; ; epiblast; ; morula; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein homodimerization activity; kinase binding; RNA binding; protein heterodimerization activity; ubiquitin-protein transferase activity; protein binding; transferase activity;
Cellular component	cytoplasm; BRCA1-A complex; BRCA1-BARD1 complex; ubiquitin ligase complex; nucleus; nucleoplasm; nuclear speck; cytoplasmic ribonucleoprotein granule;
Biological process	regulation of phosphorylation; negative regulation of apoptotic process; protein K6-linked ubiquitination; negative regulation of mRNA 3'-end processing; positive regulation of protein catabolic process; negative regulation of protein export from nucleus; double-strand break repair via nonhomologous end joining; cellular response to DNA damage stimulus; tissue homeostasis; protein ubiquitination; positive regulation of apoptotic process; DNA replication; DNA double-strand break processing; DNA repair; protein deubiquitination; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	580
	12021
	ENSG00000138376
	ENSMUSG00000026196
	Q99728
	O70445
	NM_000465; NM_001282543; NM_001282545; NM_001282548; NM_001282549
	NM_007525
NP_000456; NP_001269472; NP_001269474; NP_001269477; NP_001269478;
	NP_001269474.1
	NP_031551
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and a tandem BRCT domain (residues 568-777).