P53 upregulated modulator of apoptosis

BBC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M04, 4HNJ, 4BPI, 4BPJ, 4BPK,%%s4BPK, 4HNJ, 4BPJ, 4BPI, 2M04
Identifiers
Aliases	BBC3, JFY-1, JFY1, PUMA, BCL2 binding component 3
External IDs	OMIM: 605854; MGI: 2181667; HomoloGene: 8679; GeneCards: BBC3; OMA:BBC3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,232,766 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	16,052,130 bp
RNA expression pattern
	Top expressed in
	beta cell; ; vena cava; ; parotid gland; ; body of tongue; ; Pons; ; pericardium; ; granulocyte; ; triceps brachii muscle; ; tendon of biceps brachii; ; subthalamic nucleus;
	Top expressed in
	granulocyte; ; external carotid artery; ; internal carotid artery; ; left lung lobe; ; otic vesicle; ; lumbar spinal ganglion; ; stroma of bone marrow; ; lacrimal gland; ; subcutaneous adipose tissue; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	ATPase binding; protein binding;
Cellular component	lysosome; mitochondrion; cytosol; mitochondrial outer membrane; endoplasmic reticulum;
Biological process	apoptotic process; positive regulation of apoptotic process; positive regulation of release of cytochrome c from mitochondria; intrinsic apoptotic signaling pathway; release of cytochrome c from mitochondria; activation of cysteine-type endopeptidase activity involved in apoptotic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; execution phase of apoptosis; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of protein homooligomerization; release of sequestered calcium ion into cytosol; negative regulation of growth; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; determination of adult lifespan; response to endoplasmic reticulum stress; cellular response to DNA damage stimulus; positive regulation of IRE1-mediated unfolded protein response; positive regulation of neuron apoptotic process; apoptotic signaling pathway; positive regulation of thymocyte apoptotic process; negative regulation of endoplasmic reticulum calcium ion concentration; cellular response to hypoxia; regulation of apoptotic process; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	27113
	170770
	ENSG00000105327
	ENSMUSG00000002083
	Q96PG8; Q9BXH1
	Q99ML1
	NM_001127240; NM_001127241; NM_001127242; NM_014417
NM_133234; NM_001382549; NM_001382550; NM_001382551; NM_001382552;
	NM_001382553
NP_001120712; NP_001120713; NP_001120714; NP_055232; NP_001120712.1;
	NP_001120713.1; NP_001120714.1; NP_055232.1
NP_573497; NP_001369478; NP_001369479; NP_001369480; NP_001369481;
	NP_001369482; NP_001390600; NP_001390601; NP_001390602; NP_001390603; NP_001390604
	Wikidata
View/Edit Human	View/Edit Mouse

The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. The expression of PUMA is regulated by the tumor suppressor p53. PUMA is involved in p53-dependent and -independent apoptosis induced by a variety of signals, and is regulated by transcription factors, not by post-translational modifications. After activation, PUMA interacts with antiapoptotic Bcl-2 family members, thus freeing Bax and/or Bak which are then able to signal apoptosis to the mitochondria. Following mitochondrial dysfunction, the caspase cascade is activated ultimately leading to cell death.