BCCIP

BCCIP
Identifiers
Aliases	BCCIP, TOK-1, TOK1, BRCA2 and CDKN1A interacting protein
External IDs	OMIM: 611883; MGI: 1913415; HomoloGene: 41629; GeneCards: BCCIP; OMA:BCCIP - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	125,853,695 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	133,322,874 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; testicle; ; gonad; ; olfactory zone of nasal mucosa; ; ganglionic eminence; ; parotid gland; ; gastrocnemius muscle; ; oocyte; ; islet of Langerhans; ; rectum;
	Top expressed in
	otic placode; ; maxillary prominence; ; primitive streak; ; mandibular prominence; ; saccule; ; yolk sac; ; hair follicle; ; epiblast; ; neural layer of retina; ; triceps brachii muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; kinase regulator activity; RNA binding; tubulin binding;
Cellular component	nuclear cyclin-dependent protein kinase holoenzyme complex; nucleus; nucleoplasm; cytosol; centrosome; mitotic spindle pole; spindle pole; cytoplasm; centriole; microtubule organizing center; cytoskeleton;
Biological process	cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; neuroendocrine cell differentiation; DNA repair; cellular response to DNA damage stimulus; establishment of mitotic spindle orientation; microtubule cytoskeleton organization; mitotic spindle organization; microtubule anchoring; mitotic spindle assembly; ribosomal large subunit export from nucleus;
	Sources:Amigo / QuickGO
Orthologs
	56647
	66165
	ENSG00000107949
	ENSMUSG00000030983
	Q9P287
	Q9CWI3
	NM_078469; NM_016567; NM_078468
	NM_025392
	NP_057651; NP_510868; NP_510869
	NP_079668
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA2 and CDKN1A-interacting protein is a protein that is encoded by the BCCIP gene in humans.

This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.