Bcl-2-like protein 1

BCL2L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BXL, 1G5J, 1LXL, 1MAZ, 1R2D, 1R2E, 1R2G, 1R2H, 1R2I, 1YSG, 1YSI, 1YSN, 2B48, 2LP8, 2LPC, 2M03, 2M04, 2ME8, 2ME9, 2MEJ, 2O1Y, 2O2M, 2O2N, 2P1L, 2PON, 2YJ1, 2YQ6, 2YQ7, 2YXJ, 3CVA, 3FDL, 3FDM, 3INQ, 3IO8, 3PL7, 3QKD, 3R85, 3SP7, 3SPF, 3WIZ, 3ZK6, 3ZLN, 3ZLO, 3ZLR, 4A1U, 4A1W, 4AQ3, 4BPK, 4C52, 4C5D, 4CIN, 4EHR, 4HNJ, 4IEH, 4PPI, 4QVE, 4QVF, 4QVX, 4TUH, 5AGW, 5AGX, 4Z9V, 5FMK, 5FMJ, 5C3G
Identifiers
Aliases	BCL2L1, Bcl2l1, Bcl(X)L, Bcl-XL, Bcl2l, BclX, bcl-x, bcl2-L-1, BCL-XL/S, BCLXL, BCLXS, PPP1R52, bcl-xS, BCL2L, BCLX, Bcl-X, bcl-xL, BCL2 like 1
External IDs	OMIM: 600039; MGI: 88139; HomoloGene: 7639; GeneCards: BCL2L1; OMA:BCL2L1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	31,723,989 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,673,648 bp
RNA expression pattern
	Top expressed in
	right lung; ; olfactory zone of nasal mucosa; ; upper lobe of left lung; ; Descending thoracic aorta; ; ascending aorta; ; right coronary artery; ; islet of Langerhans; ; monocyte; ; left coronary artery; ; gallbladder;
	Top expressed in
	spermatocyte; ; fetal liver hematopoietic progenitor cell; ; blood; ; tibiofemoral joint; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; vestibular membrane of cochlear duct; ; spermatid; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	BH3 domain binding; protein binding; identical protein binding; protein kinase binding; protein homodimerization activity; protein heterodimerization activity;
Cellular component	cytoplasm; integral component of membrane; cytosol; centrosome; nuclear membrane; mitochondrial membranes; membrane; Bcl-2 family protein complex; synapse; intracellular anatomical structure; synaptic vesicle membrane; microtubule organizing center; cell junction; mitochondrial matrix; mitochondrion; mitochondrial inner membrane; cytoskeleton; cytoplasmic vesicle; nucleus; endoplasmic reticulum; mitochondrial outer membrane;
Biological process	negative regulation of neuron apoptotic process; neuron apoptotic process; germ cell development; negative regulation of execution phase of apoptosis; regulation of apoptotic process; response to cytokine; male gonad development; endocytosis; negative regulation of intrinsic apoptotic signaling pathway; mitotic cell cycle checkpoint signaling; negative regulation of release of cytochrome c from mitochondria; response to virus; negative regulation of apoptotic process; response to cycloheximide; in utero embryonic development; cellular response to alkaloid; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; regulation of mitochondrial membrane potential; regulation of mitochondrial membrane permeability; apoptotic mitochondrial changes; cellular response to gamma radiation; spermatogenesis; positive regulation of cell population proliferation; positive regulation of apoptotic process; cellular response to amino acid stimulus; ovarian follicle development; apoptotic process in bone marrow cell; fertilization; response to radiation; suppression by virus of host apoptotic process; cell population proliferation; mitochondrion morphogenesis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of autophagy; positive regulation of intrinsic apoptotic signaling pathway; negative regulation of anoikis; hepatocyte apoptotic process; release of cytochrome c from mitochondria; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand; apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; growth; negative regulation of protein localization to plasma membrane; cytokine-mediated signaling pathway; regulation of cytokinesis; regulation of growth; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	598
	12048
	ENSG00000171552
	ENSMUSG00000007659
	Q07817; Q5TE64
	Q64373
NM_001191; NM_138578; NM_001317919; NM_001317920; NM_001317921;
	NM_001322239; NM_001322240; NM_001322242
	NM_001289716; NM_001289717; NM_001289739; NM_009743; NM_001355053
NP_001182; NP_001304848; NP_001304849; NP_001304850; NP_001309168;
	NP_001309169; NP_001309171; NP_612815
	NP_001276645; NP_001276646; NP_001276668; NP_033873; NP_001341982
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2-like protein 1 is a protein encoded in humans by the BCL2L1 gene. Through alternative splicing, the gene encodes both of the human proteins Bcl-xL and Bcl-xS.