BCL2L10

BCL2L10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B4S
Identifiers
Aliases	BCL2L10, BCL-B, Boo, Diva, bcl2-L-10, BCL2 like 10
External IDs	OMIM: 606910; MGI: 1330841; HomoloGene: 8396; GeneCards: BCL2L10; OMA:BCL2L10 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	52,112,775 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,258,931 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; skin of abdomen; ; skin of leg; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; mucosa of esophagus; ; human kidney; ; left adrenal cortex; ; nucleus accumbens;
	Top expressed in
	secondary oocyte; ; blastocyst; ; primary oocyte; ; zygote; ; meninges; ; morula; ; ovary; ; cumulus cell; ; white adipose tissue; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; caspase binding; protein homodimerization activity; protein heterodimerization activity;
Cellular component	nucleus; integral component of membrane; cytosol; nuclear membrane; mitochondrion; membrane; mitochondrial outer membrane;
Biological process	apoptotic process; regulation of apoptotic process; negative regulation of apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process; female gamete generation; spermatogenesis; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10017
	12049
	ENSG00000137875
	ENSMUSG00000032191
	Q9HD36
	Q9Z0F3
	NM_001306168; NM_020396
	NM_013479
	NP_001293097; NP_065129
	NP_038507
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.