BCL2L12

BCL2L12
Identifiers
Aliases	BCL2L12, BCL2 like 12
External IDs	OMIM: 610837; MGI: 1922986; HomoloGene: 12619; GeneCards: BCL2L12; OMA:BCL2L12 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	49,673,916 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	44,648,136 bp
RNA expression pattern
	Top expressed in
	gonad; ; gastrocnemius muscle; ; muscle of thigh; ; mucosa of transverse colon; ; granulocyte; ; testicle; ; oocyte; ; right lobe of liver; ; appendix; ; right ovary;
	Top expressed in
	spermatocyte; ; hand; ; ventricular zone; ; yolk sac; ; maxillary prominence; ; mandibular prominence; ; ascending aorta; ; epiblast; ; foot; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	p53 binding; protein binding;
Cellular component	membrane; nucleus;
Biological process	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription by RNA polymerase II; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cellular senescence; apoptotic process; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	83596
	75736
	ENSG00000126453
	ENSMUSG00000003190
	Q9HB09
	n/a
NM_001040668; NM_001282516; NM_001282517; NM_001282519; NM_001282520;
	NM_001282521; NM_138639; NM_001385706
	NM_029410
NP_001035758; NP_001269445; NP_001269446; NP_001269448; NP_001269449;
	NP_001269450; NP_619580
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism. Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.