BCL2L2

BCL2L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MK3, 1O0L, 1ZY3, 2Y6W, 4CIM
Identifiers
Aliases	BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, BCL2 like 2
External IDs	OMIM: 601931; MGI: 108052; HomoloGene: 2989; GeneCards: BCL2L2; OMA:BCL2L2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,311,751 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,125,691 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; prefrontal cortex; ; Amygdala; ; right frontal lobe; ; postcentral gyrus; ; lateral nuclear group of thalamus; ; Brodmann area 9; ; orbitofrontal cortex; ; cingulate gyrus; ; muscle layer of sigmoid colon;
	Top expressed in
	medial dorsal nucleus; ; lobe of cerebellum; ; habenula; ; subiculum; ; cerebellar vermis; ; medial geniculate nucleus; ; pontine nuclei; ; ventral tegmental area; ; medial vestibular nucleus; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein homodimerization activity; disordered domain specific binding; identical protein binding; protein heterodimerization activity; BH domain binding;
Cellular component	cytoplasm; cytosol; mitochondrial membranes; mitochondrion; membrane; mitochondrial outer membrane; Bcl-2 family protein complex; nucleus; nuclear inclusion body;
Biological process	spermatogenesis; regulation of apoptotic process; negative regulation of apoptotic process; Sertoli cell proliferation; apoptotic process; intrinsic apoptotic signaling pathway in response to DNA damage; extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; cellular response to estradiol stimulus; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	599
	12050
	ENSG00000129473
	ENSMUSG00000089682
	Q92843
	P70345
	NM_004050; NM_001199839
	NM_007537
	NP_001186768; NP_004041
	NP_031563
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2-like protein 2 is a 193-amino acid protein that in humans is encoded by the BCL2L2 gene on chromosome 14 (band q11.2-q12). It was originally discovered by Leonie Gibson, Suzanne Cory and colleagues at the Walter and Eliza Hall Institute of Medical Research, who called it Bcl-w.