BH3 interacting-domain death agonist

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

BID
BID
	human pro-apoptotic protein bid
Identifiers
Symbol	BID
Pfam	PF06393
InterPro	IPR010479
SCOP2	1ddb / SCOPe / SUPFAM
TCDB	1.A.21
OPM superfamily	40
OPM protein	2m5i
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

BID
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZY3, 2BID, 2KBW, 2M5B, 2M5I, 4BD2, 4ZEQ, 5AJJ, 4QVE, 4ZIG, 4ZII, 5C3F
Identifiers
Aliases	BID, Bid, 2700049M22Rik, AI875481, AU022477, FP497, BH3 interacting domain death agonist
External IDs	OMIM: 601997; MGI: 108093; HomoloGene: 923; GeneCards: BID; OMA:BID - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	17,774,770 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	120,893,814 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; granulocyte; ; pancreatic ductal cell; ; bone marrow; ; right frontal lobe; ; bone marrow cells; ; prefrontal cortex; ; periodontal fiber; ; mucosa of transverse colon;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; otic placode; ; saccule; ; stroma of bone marrow; ; right kidney; ; human kidney; ; otic vesicle; ; proximal tubule; ; blood;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	death receptor binding; protein binding; ubiquitin protein ligase binding; protein heterodimerization activity;
Cellular component	cytoplasm; membrane; mitochondrial membranes; mitochondrial outer membrane; mitochondrion; integral component of mitochondrial membrane; cytosol;
Biological process	neuron apoptotic process; positive regulation of protein homooligomerization; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; extrinsic apoptotic signaling pathway; signal transduction in response to DNA damage; regulation of protein oligomerization; establishment of protein localization to membrane; protein targeting to mitochondrion; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of G1/S transition of mitotic cell cycle; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; regulation of cell population proliferation; apoptotic mitochondrial changes; positive regulation of protein oligomerization; positive regulation of apoptotic process; positive regulation of release of cytochrome c from mitochondria; positive regulation of extrinsic apoptotic signaling pathway; protein homooligomerization; activation of cysteine-type endopeptidase activity involved in apoptotic process; mitochondrial outer membrane permeabilization; extrinsic apoptotic signaling pathway via death domain receptors; hepatocyte apoptotic process; release of cytochrome c from mitochondria; apoptotic process; regulation of apoptotic process; positive regulation of mitochondrial membrane potential; mitochondrial ATP synthesis coupled electron transport; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; positive regulation of fibroblast apoptotic process; positive regulation of apoptotic signaling pathway; negative regulation of apoptotic process; positive regulation of intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	637
	12122
	ENSG00000015475
	ENSMUSG00000004446
	P55957
	P70444
NM_001196; NM_001244567; NM_001244569; NM_001244570; NM_001244572;
	NM_197966; NM_197967
	NM_007544
NP_001187; NP_001231496; NP_001231498; NP_001231499; NP_001231501;
	NP_932070; NP_932071; NP_001187.1; NP_001231496.1
	NP_031570
	Wikidata
View/Edit Human	View/Edit Mouse

The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.