BICD2

BICD2
Identifiers
Aliases	BICD2, SMALED2, bA526D8.1, BICD cargo adaptor 2, SMALED2B, SMALED2A
External IDs	OMIM: 609797; MGI: 1924145; HomoloGene: 9070; GeneCards: BICD2; OMA:BICD2 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	92,764,833 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	49,540,502 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; hair follicle; ; human penis; ; nipple; ; vulva; ; skin of arm; ; oral cavity; ; skin of thigh; ; skin of hip; ; mucosa of pharynx;
	Top expressed in
	Rostral migratory stream; ; internal carotid artery; ; external carotid artery; ; trigeminal ganglion; ; interventricular septum; ; myocardium of ventricle; ; right lung lobe; ; skin of external ear; ; retinal pigment epithelium; ; atrioventricular valve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; dynein light intermediate chain binding; dynactin binding; dynein complex binding; cytoskeletal anchor activity;
Cellular component	plasma membrane; Golgi apparatus; cytoskeleton; cytoplasmic vesicle; nucleus; nuclear envelope; lamellae anulatae; nuclear pore; cytoplasm; cytosol; centrosome;
Biological process	microtubule-based movement; minus-end-directed organelle transport along microtubule; microtubule anchoring at microtubule organizing center; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein transport; mRNA transport; centrosome localization; transport; protein localization to Golgi apparatus; regulation of microtubule cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	23299
	76895
	ENSG00000185963
	ENSMUSG00000037933
	Q8TD16
	Q921C5
	NM_015250; NM_001003800
	NM_001039179; NM_001039180; NM_029791
	NP_001003800; NP_056065
	NP_001034268; NP_001034269; NP_084067
	Wikidata
View/Edit Human	View/Edit Mouse

Bicaudal D cargo adaptor 2 is a protein that in humans is encoded by the BICD2 gene.

This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.

Mutations in BICD2 are associated with spinal muscular atrophy with lower extremity predominance type 2A and type 2B.