BIN1

BIN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MUZ, 1MV0, 1MV3, 2FIC, 2RMY, 2RND, 5I22
Identifiers
Aliases	BIN1, AMPH2, AMPHL, SH3P9, bridging integrator 1, CNM2
External IDs	OMIM: 601248; MGI: 108092; HomoloGene: 113707; GeneCards: BIN1; OMA:BIN1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	127,107,288 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	32,568,790 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; Skeletal muscle tissue of rectus abdominis; ; tibialis anterior muscle; ; glutes; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; thoracic diaphragm; ; deltoid muscle;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; temporal muscle; ; extensor digitorum longus muscle; ; sternocleidomastoid muscle; ; plantaris muscle; ; medial head of gastrocnemius muscle; ; neural layer of retina; ; skeletal muscle tissue; ; digastric muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA polymerase binding; identical protein binding; tau protein binding; actin filament binding; protease binding; phospholipid binding; clathrin binding; chaperone binding;
Cellular component	cytoplasm; membrane; I band; T-tubule; lipid tube; node of Ranvier; axon; Z discdkac; actin cytoskeleton; axon initial segment; nucleus; nuclear envelope; cytosol; endosome; cytoskeleton; plasma membrane; synaptic vesicle; sarcolemma; synapse;
Biological process	regulation of endocytosis; regulation of neuron differentiation; cell differentiation; endocytosis; positive regulation of astrocyte differentiation; multicellular organism development; muscle cell differentiation; positive regulation of apoptotic process; lipid tube assembly; cell population proliferation; viral process; nucleus localization; nucleus organization; membrane organization; cytoskeleton organization; endosome to lysosome transport; positive regulation of actin filament polymerization; T-tubule organization; regulation of heart rate by cardiac conduction; negative regulation of potassium ion transmembrane transport; negative regulation of amyloid-beta formation; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; negative regulation of ventricular cardiac muscle cell action potential; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel;
	Sources:Amigo / QuickGO
Orthologs
	274
	30948
	ENSG00000136717
	ENSMUSG00000024381
	O00499
	O08539
NM_004305; NM_139343; NM_139344; NM_139345; NM_139346;
	NM_139347; NM_139348; NM_139349; NM_139350; NM_139351; NM_001320632; NM_001320633; NM_001320634; NM_001320640; NM_001320641; NM_001320642
	NM_001083334; NM_009668; NM_001360876
NP_001307561; NP_001307562; NP_001307563; NP_001307569; NP_001307570;
	NP_001307571; NP_004296; NP_647593; NP_647594; NP_647595; NP_647596; NP_647597; NP_647598; NP_647599; NP_647600; NP_647601; NP_647601.1; NP_001307561.1
	NP_001076803; NP_033798; NP_001347805
	Wikidata
View/Edit Human	View/Edit Mouse

Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene.

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor.

Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin.

Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process.

Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.