Survivin

BIRC5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E31, 1F3H, 1XOX, 2QFA, 2RAW, 2RAX, 3UEC, 3UED, 3UEE, 3UEF, 3UEG, 3UEH, 3UEI, 3UIG, 3UIH, 3UII, 3UIJ, 3UIK, 4A0I, 4A0J, 4A0N
Identifiers
Aliases	BIRC5, API4, EPR-1, baculoviral IAP repeat containing 5
External IDs	OMIM: 603352; MGI: 1203517; HomoloGene: 37450; GeneCards: BIRC5; OMA:BIRC5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	78,225,636 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	117,746,569 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; left testis; ; right testis; ; mucosa of transverse colon; ; bone marrow; ; trabecular bone; ; stromal cell of endometrium; ; testicle;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; primary oocyte; ; otic placode; ; endocardial cushion; ; zygote; ; maxillary prominence; ; mandibular prominence; ; dermis; ; abdominal wall; ; blastocyst;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; cobalt ion binding; chaperone binding; protein homodimerization activity; metal ion binding; ubiquitin-protein transferase activity; tubulin binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; identical protein binding; protein heterodimerization activity; enzyme binding; microtubule binding; zinc ion binding; cysteine-type endopeptidase inhibitor activity;
Cellular component	cytosol; spindle; chromosome; nucleoplasm; chromosome passenger complex; nuclear chromosome; interphase microtubule organizing center; spindle microtubule; centriole; cytoplasmic microtubule; cytoskeleton; microtubule; kinetochore; midbody; cytoplasm; chromosome, centromeric region; nucleus;
Biological process	negative regulation of peptidase activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of transcription, DNA-templated; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; establishment of chromosome localization; chromosome segregation; positive regulation of mitotic cell cycle; positive regulation of exit from mitosis; transcription, DNA-templated; cell division; protein phosphorylation; mitotic spindle assembly; regulation of signal transduction; G2/M transition of mitotic cell cycle; positive regulation of cell population proliferation; protein-containing complex localization; cell cycle; negative regulation of transcription, DNA-templated; apoptotic process; regulation of apoptotic process; negative regulation of apoptotic process; regulation of mitotic cell cycle; mitotic cell cycle; hearing; mitotic cytokinesis; mitotic spindle assembly checkpoint signaling; cytokine-mediated signaling pathway; protein ubiquitination; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
	332
	11799
	ENSG00000089685
	ENSMUSG00000017716
	O15392
	O70201
	NM_001012270; NM_001012271; NM_001168
	NM_001012272; NM_001012273; NM_009689
	NP_001012270; NP_001012271; NP_001159
	NP_001012273; NP_033819
	Wikidata
View/Edit Human	View/Edit Mouse

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.

Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.