BIRC7

BIRC7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OXN, 1OXQ, 1OY7, 1TW6, 2I3H, 2I3I, 3F7G, 3F7H, 3F7I, 3GT9, 3GTA, 3UW5, 4AUQ
Identifiers
Aliases	BIRC7, KIAP, LIVIN, ML-IAP, MLIAP, RNF50, baculoviral IAP repeat containing 7
External IDs	OMIM: 605737; MGI: 2676458; HomoloGene: 51405; GeneCards: BIRC7; OMA:BIRC7 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,240,495 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	180,575,803 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; sural nerve; ; placenta; ; right adrenal cortex; ; right lung; ; gonad; ; skin of leg; ; skin of abdomen; ; lymph node; ; C1 segment;
	Top expressed in
	lens; ; epithelium of lens; ; set of lens fibers; ; ankle; ; embryo; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; primary visual cortex; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity; metal ion binding; ubiquitin-protein transferase activity; protein binding; enzyme binding; transferase activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ubiquitin protein ligase activity;
Cellular component	cytoplasm; Golgi apparatus; nucleus; microtubule organizing center; cytosol;
Biological process	negative regulation of peptidase activity; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; regulation of natural killer cell apoptotic process; mitotic spindle assembly; regulation of cell population proliferation; regulation of signal transduction; protein ubiquitination; apoptotic process; positive regulation of protein ubiquitination; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	79444
	329581
	ENSG00000101197
	ENSMUSG00000038840
	Q96CA5
	A2AWP0
	NM_139317; NM_022161
	NM_001163247
	NP_071444; NP_647478
	NP_001156719
	Wikidata
View/Edit Human	View/Edit Mouse

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.

The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide. In melanoma, BIRC7 gene expression is regulated by the Microphthalmia-associated transcription factor.