Bleomycin hydrolase

BLMH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CB5, 2CB5
Identifiers
Aliases	BLMH, BH, BMH, bleomycin hydrolase
External IDs	OMIM: 602403; MGI: 1345186; HomoloGene: 330; GeneCards: BLMH; OMA:BLMH - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,292,056 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	76,878,205 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of leg; ; skin of abdomen; ; skin of thigh; ; epithelium of colon; ; body of pancreas; ; Descending thoracic aorta; ; mucosa of esophagus; ; stromal cell of endometrium; ; body of uterus;
	Top expressed in
	fossa; ; condyle; ; primitive streak; ; hair follicle; ; renal corpuscle; ; internal carotid artery; ; esophagus; ; vas deferens; ; external carotid artery; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; hydrolase activity; carboxypeptidase activity; cysteine-type endopeptidase activity; protein binding; cysteine-type peptidase activity; aminopeptidase activity; identical protein binding;
Cellular component	extracellular exosome; cytosol; nucleus; cytoplasm;
Biological process	protein polyubiquitination; proteolysis; response to toxic substance; homocysteine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	642
	104184
	ENSG00000108578
	ENSMUSG00000020840
	Q13867
	Q8R016
	NM_000386
	NM_178645
	NP_000377
	NP_848760
	Wikidata
View/Edit Human	View/Edit Mouse

Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene.

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone. Another of its activities is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.