B-cell linker

BLNK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EO6
Identifiers
Aliases	BLNK, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, bca, B-cell linker, B cell linker
External IDs	OMIM: 604515; MGI: 96878; HomoloGene: 32038; GeneCards: BLNK; OMA:BLNK - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	96,271,587 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	40,982,978 bp
RNA expression pattern
	Top expressed in
	oral cavity; ; corpus epididymis; ; spleen; ; jejunal mucosa; ; duodenum; ; epithelium of nasopharynx; ; appendix; ; mucosa of pharynx; ; lymph node; ; right lobe of liver;
	Top expressed in
	spleen; ; mesenteric lymph nodes; ; molar; ; left colon; ; seminal vesicula; ; tail of embryo; ; submandibular gland; ; temporal muscle; ; Ileal epithelium; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane receptor protein tyrosine kinase adaptor activity; protein binding;
Cellular component	cytosol; membrane; cytoplasm; intracellular anatomical structure; plasma membrane; cytoplasmic ribonucleoprotein granule;
Biological process	humoral immune response; B cell differentiation; intracellular signal transduction; B cell activation; inflammatory response; positive regulation of signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	29760
	17060
	ENSG00000095585
	ENSMUSG00000061132
	Q8WV28
	Q9QUN3
	NM_001114094; NM_001258440; NM_001258441; NM_001258442; NM_013314
	NM_008528; NM_001365054
	NP_001107566; NP_001245369; NP_001245370; NP_001245371; NP_037446
	NP_032554; NP_001351983
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell linker (BLNK) protein is expressed in B cells and macrophages and plays a large role in B cell receptor signaling. Like all adaptor proteins, BLNK has no known intrinsic enzymatic activity. Its function is to temporally and spatially coordinate and regulate downstream signaling effectors in B cell receptor (BCR) signaling, which is important in B cell development. Binding of these downstream effectors is dependent on BLNK phosphorylation. BLNK is encoded by the BLNK gene and is also known as SLP-65, BASH, and BCA.