BMF (gene)

BMF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VOG
Identifiers
Aliases	BMF, Bcl2 modifying factor
External IDs	OMIM: 606266; MGI: 2176433; HomoloGene: 14130; GeneCards: BMF; OMA:BMF - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	40,108,892 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	118,380,168 bp
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow cells; ; granulocyte; ; islet of Langerhans; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gallbladder; ; spleen; ; appendix; ; duodenum;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; medullary collecting duct; ; hand; ; trigeminal ganglion; ; left lung lobe; ; vas deferens; ; superior cervical ganglion; ; utricle; ; prostate;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	mitochondrial outer membrane; cytosol; plasma membrane; acrosomal vesicle; myosin complex;
Biological process	positive regulation of protein homooligomerization; positive regulation of release of cytochrome c from mitochondria; anoikis; positive regulation of intrinsic apoptotic signaling pathway; protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; apoptotic process; positive regulation of apoptotic process; negative regulation of autophagy; cellular response to UV;
	Sources:Amigo / QuickGO
Orthologs
	90427
	171543
	ENSG00000104081
	ENSMUSG00000040093
	Q96LC9
	Q91ZE9
	NM_001003940; NM_001003942; NM_001003943; NM_033503
	NM_138313; NM_001311140; NM_001331221
	NP_001003940; NP_001003942; NP_001003943; NP_277038
	NP_001298069; NP_001318150; NP_612186
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-2-modifying factor is a protein that in humans is encoded by the BMF gene.

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.